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Services
The LJINCC Neuropathology
Core is available for all UCSD researchers and members of the
La Jolla Interdisciplinary Neuroscience Center
program.
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Expert support and
evaluation of the neuropathology in neurological disorders
(inflammatory, degeneration, ischemia) in human tissues, rodents,
macaques and invertebrates.
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Immunocytochemistry,
single, double and triple labeling of sections, tissue culture.
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Tissue bank of
human brains from AD, PD, HD, controls and other neurological
disorders. Tissue repository of nontg and APP and synuclein tg mice.
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Tissue processing
for histochemistry and immunocytochemistry. Fixation, embedding,
sectioning (vibratome, frozen, paraffin), antibody labeling. Silver
and fluorescent stains.
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Confocal scanning
laser microscopy of brain tissue sections and tissue culture.
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Electron
microscopy: Tissue embedding, ultrathin sectioning, electron
micrographs, serial sections, and staining.
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Immunogold and
immuno-electron microcopy.
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Image analysis,
digital microscopy, morphometry, stereology, planimetry optical
density, pixel intensity.
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Analysis of
synaptic damage, neuroinflamation and selective neuronal populations
by immunolabeling.
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Immunoblot assays
for protein aggregation and processing.
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Expert consultation
in studies in transgenic mice
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Expert consultation
in studies involving lentiviral vectors and rodent surgery.
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Special
neuropathological and biochemical assays for autophagy, neurogenesis
and apoptosis.
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