|
||
|
Core Services Blueprint-funded La Jolla Neuroscience Center Cores play a critical role in the advancement of neuroscience research in San Diego and environs. These services allow neuroscientists to take advantage of sophisticated technologies available across all 4 institutions. Below are the core services provided through the La Jolla Interdisciplinary Neurosciences Center. Please click on the core service for more information: _______________________________________________________________________________________________________________________________________ BEHAVIORAL SCIENCES The Behavioral Core provides mouse behavioral assessments to allow investigators to make transitions from laboratory findings to clinical applications by enabling the modeling of human diseases and the development of medications and other treatment strategies. _______________________________________________________________________________________________________________________________________ Bioinformatics BIMR Bioinformatics | Salk Bioinformatics The Bioinformatics Core operates two facilities: Bioinformatics Facility at Salk, which specializes in gene promoter and evolutionary sequence analysis, and B) Bioinformatics at BIMR that emphasizes structural biology, gene and miRNA expression profiling and proteomics. ________________________________________________________________________________________________________________________________________ Cell Imaging and Histology BIMR Cell Imaging | BIMR Histology The Cell Imaging and Histology Core consists of two interconnected facilities located at BIMR: the Cell Imaging Facility, which provides expert services enabling imaging experiments on a wide range of microscope imaging systems, and the Histology Facility, which provides access, training and services in tissue processing, histology, immunohistochemistry and neurohistopathology. The two facilities share adjacent space on the BIMR campus and an integrated management hierarchy. _______________________________________________________________________________________________________________________________________ BIMR Assay Development | BIMR Chemical Library Screening | BIMR Cheminformatics | BIMR High-content Screening The Chemical Library Screening core offers high-throughput screening (HTS) of biochemical and cell-based array using traditional HTS readouts and automated microscopy for high-content screening (HCS)> These facilities also offer array development and screening, as well as cheminformatics and medicinal chemistry. _______________________________________________________________________________________________________________________________________ BIMR Electrophysiology | Salk Electrophysiology The Electrophysiology Core consists of two facilities. Salk Electrophysiology Facility and Burnham Electrophysiology Facility. Both facilities can perform patch-clamp intracellular and extracellular field recordings on a range of material including cultured cells and brain slices. The Salk facility emphasizes acute and cultured brain slices as well as cultured cells, whereas the BIMR facility emphasizes electrophysiological analysis of cultured cells and the detailed electrical properties of channels, receptors and recombinant proteins expressed in Xenopus oocytes or mammalian cells. _______________________________________________________________________________________________________________________________________ BIMR Gene Analysis DNA Analysis | Microarray/qPCR | Salk Microarray The Gene Analysis Core has two facilities: Gene Analysis Facility at BIMR that provides DNA sequence analysis, PCR-genotyping, quantitative PCR and Illumina microarray analysis, and the Microarray Facility at Salk, that offers Affymetrix microarray analysis, quantitative PCR, and automated plasmid preparation. _______________________________________________________________________________________________________________________________________ The Flow Cytometry core provides analytical cytometry and high speed flow sorting of labeled cells. _______________________________________________________________________________________________________________________________________ Neuropathology The Neuropathology laboratory applies immunocytochemistry, neurochemistry, molecular genetics, transgenic models of disease, and imaging by scanning laser confocal microscopy to analysis of neurological disease in animal models. _______________________________________________________________________________________________________________________________________ BIMR Proteomics | TSRI Proteomics | Salk Proteomics The Proteomics Core has three facilities: Proteomics at BIMR, Mass Spectrometry Facility at Salk, and Proteomics at TSRI. The three facilities bring a wide range of complementary services to Blueprint investigators. _______________________________________________________________________________________________________________________________________ BIMR Stem Cell | Salk Stem Cell The Stem Cell Core operates out of two facilities: Stem Cell Facility at BIMR that focuses on hESCs and hESC-derived neural progenitor cells and the Stem Cell Facility at Salk that emphases neural stem cells and their differentiated derivatives. _______________________________________________________________________________________________________________________________________ BIMR Structural Biology X-Ray | Nuclear Magnetic Facility | Protein Production Salk Structural Biology X-Ray | Nuclear Magnetic Facility The Structural Biology Core has two facilities: Structural Biology Facility at BIMR that offers X-ray Crystallography, NMR Spectroscopy, and Protein Production, and Structural Biology Facility at Salk that also provides X-ray crystallography and NMR Spectroscopic analyses of biological macromolecules. _______________________________________________________________________________________________________________________________________ Viral Vectors and Functional Genomics BIMR Viral Vector | BIMR Functional Genomics | Salk Viral Vector The Viral Vectors and Functional Genomics Core has three facilities: Viral Vector Facility at Salk, specializing in very high titer lentivirus and recombinant adeno-associated virus, and in design and construction of lentiviral vectors to deliver shRNAs ; Viral Vector facility at BIMR, specializing in lentiviral and adenoviral vector construction and preparation; and Functional Genomics at BIMR, specializing in automated high throughput microRNA and siRNA oligonucleotide screening.
Last update 01.04.10 |
||
